Low-dose regimens have been tested in fibromyalgia and multiple sclerosis because transient opioid receptor blockade may trigger a compensatory increase in endogenous opioid signaling. For alcohol dependence treatment, the OPRM1 A118G polymorphism is linked to a significantly better drinking-reduction response in some cohorts. A meta-analysis of Naltrexone uses and benefits notes that effect sizes for cue-induced craving shrink markedly after treatment discontinuation.
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